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DOI: 10.1055/s-2006-957346
© Georg Thieme Verlag KG Stuttgart · New York
Positive Correlation of Galanin with Glucose in Healthy Volunteers during an Oral Glucose Tolerance Test
Publikationsverlauf
Received 12. 6. 2006
Accepted 16. 10. 2006
Publikationsdatum:
16. Januar 2007 (online)
![](https://www.thieme-connect.de/media/hmr/200701/lookinside/thumbnails/10.1055-s-2006-957346-1.jpg)
Abstract
Galanin has been found in increased amounts in subjects with type 2 diabetes. The purpose of the present study was to determine the levels of galanin in healthy volunteers during an oral glucose tolerance test (OGTT). We enrolled 11 healthy volunteers, 4 males aged 48±3.56 years with BMI 27±0.5 kg/m2 and 7 females aged 41.3±3.05 years with BMI 27.6±0.9 kg/m2. All were in good health without cardiac, hepatic, renal or other chronic disease. None were taking any medication affecting glucose tolerance (β-blockers, thiazide diuretics, and corticoids) and none had a first degree relative with type 2 diabetes. Glucose tolerance was determined by using the International Expert Committee criteria. Blood samples were collected at 0, 30, 60, 90, 120 and 180 minutes for the measurement of plasma glucose, insulin, C-peptide and human galanin (hGal). During the OGTT, hGal exhibited a significant increase from time 0 to 90 minutes (p < 0.001) and returned to the basal values at 180 minutes, while a positive correlation of blood glucose with hGal was observed during the time scale of OGTT. A significant increase was detected both in insulin and C-peptide from the early beginning of the test at 30 minutes, which remained steady until 90 minutes, and returned gradually to the basal values at 180 minutes. No relationship was found either between hGal and serum insulin, or between hGal and serum C-peptide among the healthy subjects, during the OGTT.
Key words
tolerance - insulin - C-peptide - fasting state - homeostasis
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Correspondence
I. N. Legakis
Department of Endocrinology
“Henry Dunant” Hospital
27, Navarinou Street
155 62 Athens
Greece
Telefon: +3021065 26 655
Fax: +3021060 02 975
eMail: ilegak@med.uoa.gr