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Semin Respir Crit Care Med 2006; 27(6): 574-580
DOI: 10.1055/s-2006-957329
Published by Thieme Medical Publishers, Inc., 333 Seventh Avenue, New York, NY 10001, USA.

Host-Environment Interactions in Pulmonary Fibrosis

Stavros Garantziotis1 , 2 , David A. Schwartz2
  • 1Division of Allergy, Pulmonary, and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina
  • 2National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina
Further Information

Publication History

Publication Date:
29 December 2006 (online)

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ABSTRACT

Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the pulmonary parenchyma, leading to respiratory failure and death. Several epidemiological and theoretical observations link the pathogenesis of this disease to environmental injury to the lungs. We discuss the theoretical framework of this hypothesis and we present data in support of the concept that genetic and nongenetic host susceptibility may interact with repetitive environmental injury to lead to IPF.

KEYWORDS

Idiopathic pulmonary fibrosis - host susceptibility - environmental triggers

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David A SchwartzM.D. M.P.H. 

National Institute of Environmental Health Sciences and National Toxicology Program

P.O. Box 12233, MD:B2-01, Research Triangle Park, NC 27709-2233

Email: schwartzd@niehs.nih.gov