Synlett 2006(20): 3521-3524  
DOI: 10.1055/s-2006-956488
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© Georg Thieme Verlag Stuttgart · New York

Organocatalytic Asymmetric Synthesis of 1,2,3-prim,sec,sec-Triols

Gui-Ling Zhao, Pawel Dziedzic, Ismail Ibrahem, Armando Córdova*
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden
Fax: +46(8)154908; e-Mail: acordova@organ.su.se;
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Publication History

Received 30 August 2006
Publication Date:
08 December 2006 (online)

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Abstract

A tandem organocatalytic asymmetric synthesis of 1,2,3-triols using a,b-unsaturated aldehydes as the substrates and hydrogen peroxide as the oxidant is presented. The reaction can also be applied to the asymmetric synthesis of 3-chloro-1,2-propandiols.