Synlett 2006(20): 3399-3402  
DOI: 10.1055/s-2006-956454
LETTER
© Georg Thieme Verlag Stuttgart · New York

Asymmetric Organocatalytic Synthesis of cis-Substituted ­Dihydrobenzofuranols via Intramolecular Aldol Reactions

Dieter Enders*a, Oliver Niemeiera, Leo Straverb
a Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany
Fax: +49(241)8092127; e-Mail: enders@rwth-aachen.de;
b Bruker AXS B. V., Application SCD, Oostsingel 209, 2600AV Delft, The Netherlands
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Publikationsverlauf

Received 28 September 2006
Publikationsdatum:
08. Dezember 2006 (online)

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Abstract

The diastereo- and enantioselective synthesis of 3-hydroxy 2,3-dihydrobenzofurans via an intramolecular cis-selective aldol reaction employing proline-type organocatalysts is described enabling a new entry to coumarine natural products.