RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2007(2): 0129-0129
DOI: 10.1055/s-2006-955763
DOI: 10.1055/s-2006-955763
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of an NK-1 Receptor Antagonist
J. T. Kuethe*, J.-F. Marcoux, A. Wong, J. Wu, M. C. Hillier, P. G. Dormer, I. W. Davies, D. L. Hughes
Merck & Company, Rahway, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. Januar 2007 (online)
![](https://www.thieme-connect.de/media/synfacts/200702/lookinside/thumbnails/10.1055-s-2006-955763-1.jpg)
Significance
Neurokinin-1 (NK-1) is implicated in numerous disorders such as anxiety, asthma, emesis, cystitis migraine, pain and psoriasis. A major challenge in the synthesis of the NK-1 receptor antagonist depicted above was the stereoselective construction of the ether link between two hindered secondary alkyl centers. A detailed mechanistic study established conditions for the etherification through an unprecedented SN2 mechanism under typical SN1 conditions.