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Synfacts 2007(1): 0112-0112  
DOI: 10.1055/s-2006-955685
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York

Heteropolyacid-Functionalized Silica Catalyst for the Acylal Formation

Contributor(s): Yasuhiro Uozumi, Takayasu Arakawa
J. Wang, L. Yan, G. Qian, K. Yang, H. Liu, X. Wang*
Lanzhou Institute of Chemical Physics and Graduate School of the Chinese Academy of Sciences, Beijing, P. R. of China
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Publikationsverlauf

Publikationsdatum:
15. Dezember 2006 (online)

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Significance

A facile and versatile method for the chemoselective acylal formation of aldehydes by using a heteropolyacid-functionalized silica catalyst (SiPW-8 1) was developed. Thus, the acylal formation of benzaldehyde was carried out under solvent-free conditions with 1 and Ac2O (2 mol equiv) to give the corresponding acylal in 95% yield. Catalyst 1 was reused without loss of catalytic activity [96% (2nd use of 1); 95% (3nd use of 1), 94% (4th use of 1)]. The acylal formation of various aldehydes by using 1 was also demonstrated (11 examples, 89-98% yield).