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Synfacts 2006(12): 1250-1250  
DOI: 10.1055/s-2006-955638
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

(H8-BINOLate)Ti-Based Catalyzed Asymmetric Methallylation of Ketones

Contributor(s): Mark Lautens, Frédéric Ménard
J. G. Kim, E. H. Camp, P. J. Walsh*
University of Pennsylvania, Philadelphia, USA
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Publikationsdatum:
22. November 2006 (online)

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Significance

Enantioselective allylation of ketones represents an area of intense research because their additions are more challenging than the analogous reactions of aldehydes. Based on their earlier work in this field with allylation of ketones (K. M. Waltz, J. Gavenonis, P. J. Walsh Angew. Chem. Int. Ed. 2002, 41, 3697-3699), the authors developed a similar catalyst system for the first catalytic asymmetric methallylation of ketones.