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DOI: 10.1055/s-2006-955635
Rhodium-Catalyzed Synthesis of Chiral Aryl Glycines
G. Shang, Q. Yang, X. Zhang*
The Pennsylvania State University, University Park, USA
Publikationsverlauf
Publikationsdatum:
22. November 2006 (online)
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Significance
Chiral aryl glycines are biologically relevant compounds that received a great deal of attention over the last years. They can be prepared by aminohydroxylation (K. L. Reddy, K. B. Sharpless J. Am. Chem. Soc. 1998, 120, 1207-1217), amination of enolates (D. A. Evans, S. G. Nelson J. Am. Chem. Soc. 1997, 119, 6452-6453) or reductive amination (R. Kadyrov, T. H. Riermeier, U. Dingerdissen, V. Tararov, A. Börner J. Org. Chem. 2003, 68, 4067-4070) but in some cases low regioselectivity, high catalyst loading or poor reactivity is observed. The authors applied their recently developed TangPhos ligand (Angew. Chem. Int. Ed. 2002, 41, 1612-1614) to the enantioselective hydrogenation of a variety of α-imino esters.