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Synfacts 2006(12): 1204-1204  
DOI: 10.1055/s-2006-955603
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (S)-Venlafaxine

Contributor(s): Philip Kocienski
H. M. L. Davies*, A. Ni
State University of New York at Buffalo, USA
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Publication History

Publication Date:
22 November 2006 (online)

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Significance

The key step in this brief synthesis of the antidepressant (S)-Venlafaxine is a catalytic asymmetric C-H insertion between methyl aryldiazoacetate B and the bis-silyl-protected methylamine derivative A.