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Synfacts 2006(12): 1206-1206  
DOI: 10.1055/s-2006-955599
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (±)-Nominine

Contributor(s): Philip Kocienski
K. M. Peese, D. Y. Gin*
University of Illinois, Urbana, USA
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Publikationsverlauf

Publikationsdatum:
22. November 2006 (online)

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Significance

Nominine is an antiarrhythmic agent. It was first synthesised in 2004 by Muratake and Natsume (Angew. Chem. Int. Ed. 2004, 43, 4646-4649). The synthesis depicted here is shorter and benefits from deft use of [3+2] and [4+2] cycloadditions to construct the heptacyclic skeleton.