Flow mediated dilation and circulating oxidizedLDL(oxLDL), selectin-P, platelet activating factor acetyl hydrolase (PAF-AH), and paraoxonase (PON) to evaluate vascular risk

Problemstellung: There a substantial evidence that oxLDL are present in vivo within atherosclerotic lesion. Paraoxonase(PON)-a measure of serum antioxidant capacity- may block inflammatory responses by preventing the oxidation of LDL. The present study try to investigate the value of oxLDL and PON in patients with coronary artery disease(CAD) and their correlation with severity of endothelial dysfunction and with others markers of inflammation(PAF-AH, PON)

Patienten und Methode:The study groups included 50 patients with CAD grI and 50 patients with systemic lupus erithematous(SCL)(10 patients with CADgrII and 40 patients without CADgrIII) Patients evaluation included; clinical exam, ECG, B-mode ultrasound of brachial artery with endotelium-depend response (FMD), routine laboratory test. There were determinated the circulating level of oxLDL, PAF-AH, selectin-P and PON by spectrophotometric and ELISA methods.

Ergebnisse: In CAD patients the values of oxLDL (41,05±11grI) were lower compared to SLE patients (grII 80,67±21 and grIII79,16±18) SerumPAR-AH and selectinP was high especiality in patients with LES and CAD(grII 437.65±85 and 13.02±5). The mean value of PON was low 45±12 in all patients. FMDmeasurements showed an increase of only15–20% of the vessel diameter in grIII, 15–30% in grII and 20–30% in grI

Schlussfolgerungen: Free circulating oxLDLis low in patients with CAD comparative wirh SLE patients possible related to antianginal treatment. The inflammatory patern for vascular risk seems to correlate with low level of PON, high PAF-AH activity, high level of Pselectin.