Synthetic Applications of Oxone^®

Introduction

Oxone^® consists of 2KHSO₅ ^. KHSO₄ ^. K₂SO₄; its active component is potassium peroxymonosulfate (KHSO₅), a powerful oxidizing agent in synthetic organic chemistry which has proved to be a versatile reagent for various organic transformations. Oxone^® is commercially available and can be used immediately. Apart from its well-known applications as oxidizing agent in some transformations reviewed by Narsaiah, [1] it has found a number of other ­applications in synthetic chemistry in recent years, such as deprotection of functional groups, functional-group transformations, and cleavage of linker molecules from solid support. It has also shown wide potential in chiral ketone-catalysed asymmetric epoxidation of alkenes [2] leading to a variety of natural product skeletons, where its unique ­regioselective properties gave excellent results for the preparation of key intermediates.

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