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Synthesis 2006(24): 4121-4123
DOI: 10.1055/s-2006-950373
DOI: 10.1055/s-2006-950373
SHORTPAPER
© Georg Thieme Verlag Stuttgart · New York
Bismuth(III) Triflate Catalyzed Condensation of Isatin with Indoles and Pyrroles: A Facile Synthesis of 3,3-Diindolyl- and 3,3-Dipyrrolyl Oxindoles
Further Information
Received
10 March 2006
Publication Date:
21 November 2006 (online)
Publication History
Publication Date:
21 November 2006 (online)
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Abstract
Indoles and pyrroles undergo a rapid condensation with isatin in the presence of 2 mol% of Bi(OTf)3, under mild reaction conditions, to afford the corresponding 3,3-di(3-indolyl)- and 3,3-di(2-pyrroryl)oxindoles in excellent yields and high regioselectivity. This method is ideal for the direct introduction of indoles and pyrroles onto an isatin moiety at the 3-position.
Keywords
bismuth - Bi(OTf)3 - oxindoles - 3,3-diindolyl oxindoles - 3,3-dipyrrolyl oxindoles
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