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Synthesis 2006(24): 4200-4204
DOI: 10.1055/s-2006-950342
DOI: 10.1055/s-2006-950342
PAPER
© Georg Thieme Verlag Stuttgart · New York
First Example of Lewis Acid Catalyzed 3-Substituted 5-Arylidene-1-methyl-2-thiohydantoin Formation
Further Information
Received
15 June 2006
Publication Date:
02 November 2006 (online)
Publication History
Publication Date:
02 November 2006 (online)
Abstract
A survey of Lewis acids was conducted to facilitate the formation of arylidenethiohydantoins. The use of indium(III) triflate shows significant advantages in facilitating this reaction. In most examples, the Lewis acid promoted catalysis gave shorter reaction times, higher conversion, and better purity profiles as compared to the traditional uncatalyzed reactions.
Key words
Lewis acids - catalysis - heterocycles - indium - condensation
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