Synlett 2006(17): 2747-2750  
DOI: 10.1055/s-2006-950260
LETTER
© Georg Thieme Verlag Stuttgart · New York

Nanocrystalline Magnesium Oxide Stabilized Palladium(0): An Efficient Heterogeneous Catalyst for Heck and Sonogashira Coupling of Aryl Halides [1]

M. Lakshmi Kantam*a, Sarabindu Roya, Moumita Roya, M. S. Subhasa, Pravin R. Likhara, Bojja Sreedhara, B. M. Choudaryb
a Indian Institute of Chemical Technology, Inorganic & Physical Chemistry Division, Hyderabad 500007, India
Fax: +91(40)27160921; e-Mail: mlakshmi@iict.res.in;
b Ogene Systems (I) Pvt. Ltd., Hyderabad 500037, India
Further Information

Publication History

Received 30 July 2006
Publication Date:
09 October 2006 (online)

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Abstract

Nanocrystalline magnesium oxide supported palladium(0) catalyst [NAP-Mg-Pd(0)], prepared by the counter-ion stabilization of PdCl4 2- followed by reduction with hydrazine hydrate, was effectively used in the Heck olefination of haloarenes (chloro, bromo, and iodo) to afford good to excellent yields of substituted olefins. This ligand-free heterogeneous NAP-Mg-Pd(0) catalyst was quantitatively recovered from the reaction by a simple filtration and reused for a number of cycles with almost no loss of activity. Moreover, NAP-Mg-Pd(0) efficiently catalyzed the Sonogashira coupling of haloarenes with terminal alkynes without any copper co-catalyst under milder conditions to afford excellent yields of substituted alkynes.

1

IICT communication No. 060818.