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Synlett 2006(17): 2853-2854
DOI: 10.1055/s-2006-950248
DOI: 10.1055/s-2006-950248
SPOTLIGHT
© Georg Thieme Verlag Stuttgart · New York
Nazarov Reagent: A Novel Reagent for the Synthesis of Natural Products
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
09. Oktober 2006 (online)
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Introduction
The Nazarov reagent (ethyl-3-oxo-4-pentenoate) is frequently used as an annulating agent in many important reactions. Annulation reaction comprises Michael and Aldol condensations and is used for the construction of molecular scaffolds which constitute the core structure of many natural products. This reagent generates different classes of natural products, mainly steroids, cardenolides, terpenoids, antibiotics and alkaloids. Modified Nazarov reagents have been used for generating diverse chemical scaffolds. [1]
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