Synlett 2006(17): 2853-2854  
DOI: 10.1055/s-2006-950248
SPOTLIGHT
© Georg Thieme Verlag Stuttgart · New York

Nazarov Reagent: A Novel Reagent for the Synthesis of Natural Products

Tanpreet Kaur*
Division of Organic Chemistry (Synthesis), National Chemical ­Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India
e-Mail: t.kaur@ncl.res.in;
Further Information

Publication History

Publication Date:
09 October 2006 (online)

Introduction

The Nazarov reagent (ethyl-3-oxo-4-pentenoate) is frequently used as an annulating agent in many important ­reactions. Annulation reaction comprises Michael and ­Aldol condensations and is used for the construction of molecular scaffolds which constitute the core structure of many natural products. This reagent generates different classes of natural products, mainly steroids, cardenolides, terpenoids, antibiotics and alkaloids. Modified Nazarov reagents have been used for generating diverse chemical scaffolds. [1]