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Synfacts 2006(12): 1238-1238  
DOI: 10.1055/s-2006-949495
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Pd-Catalyzed Allylic Alkylation of Nitromethane and its Application

Contributor(s): Hishashi Yamamoto, Joshua P. Abell
T. Nemoto, L. Jin, H. Nakamura, Y. Hamada*
Chiba University, Japan
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Publication History

Publication Date:
22 November 2006 (online)

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Significance

Several methods for asymmetric allylic alkylation exist which can introduce various nucleophiles such as nitrogen, sulfur and oxygen. This reaction is often plagued by side reactions or multiple alkylations. The authors describe the allylic alkylation of nitromethane and show its use in the synthesis of two natural products.