RSS-Feed abonnieren
Bitte kopieren Sie die angezeigte URL und fügen sie dann in Ihren RSS-Reader ein.
https://www.thieme-connect.de/rss/thieme/de/10.1055-s-00000131.xml
Synfacts 2006(10): 1067-1067
DOI: 10.1055/s-2006-949374
DOI: 10.1055/s-2006-949374
Organo- and Biocatalysis
© Georg Thieme Verlag Stuttgart · New York
New Formamide Catalyst for Ketone Reductions with Trichlorosilane
K. Ogura, Y. Kouchi, F. Iwasaki, O. Onomura, Y. Matsumura*
Nagasaki University, Japan
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. September 2006 (online)
![](https://www.thieme-connect.de/media/synfacts/200610/lookinside/thumbnails/10.1055-s-2006-949374-1.jpg)
Significance
Various arylketones 2 could be reduced with trichlorosilane in the presence of a catalytic amount of formamide 1. The enantiomerically enriched alcohols 3 were generated in good yields (61-94%) and excellent enantiomeric ratios (from 96:4 to >99:1). Other reducable groups were preserved. No decrease in yield and selectivity was observed after five recovering/reusing cycles. Starting from lactone 5, which is produced by the reported method followed by cyclization, several biologically active compounds can be synthesized.