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Synfacts 2006(10): 1033-1033
DOI: 10.1055/s-2006-949338
DOI: 10.1055/s-2006-949338
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Cyanation of Aldehydes Catalyzed by a Multicomponent Titanium Complex
S. Gou, X. Chen, Y. Xiong, X. Feng*
Sichuan University, Chengdu, P. R. of China
Further Information
Publication History
Publication Date:
21 September 2006 (online)
Significance
High enantioselectivity has been achieved for the cyanation of aldehydes. A novel multicomponent bifunctional catalyst system has been designed and optimized for this reaction. In order to activate the nucleophile, the use of a 5,5′-dibromo BINOL as the ligand for the titanium Lewis acid and an amino alcohol/cinchonine combination as Lewis bases generates the reactive and selective system.