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Synfacts 2006(10): 0987-0987
DOI: 10.1055/s-2006-949330
DOI: 10.1055/s-2006-949330
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (±)-Haouamine A
P. S. Baran*, N. Z. Burns
The Scripps Research Institute, La Jolla, USA
Further Information
Publication History
Publication Date:
21 September 2006 (online)
![](https://www.thieme-connect.de/media/synfacts/200610/lookinside/thumbnails/10.1055-s-2006-949330-1.jpg)
Significance
Isolated from the tunicate Aplidium haouarianum, haouamine A exhibits selective activity against human colon cancer. Haouamine A exists as an inseparable mixture of isomers due to inversion of the nitrogen in the tetrahydropyridine ring. In addition, the highly strained paracyclophane moiety contains a bent aromatic ring.