Download PDF
Synfacts 2006(10): 0987-0987  
DOI: 10.1055/s-2006-949330
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (±)-Haouamine A

Contributor(s): Philip Kocienski, Thomas Snaddon
P. S. Baran*, N. Z. Burns
The Scripps Research Institute, La Jolla, USA
Further Information

Publication History

Publication Date:
21 September 2006 (online)

   Permissions and Reprints

Significance

Isolated from the tunicate Aplidium haouarianum, haouamine A exhibits selective activity against human colon cancer. Haouamine A exists as an inseparable mixture of isomers due to inversion of the nitrogen in the tetrahydropyridine ring. In addition, the highly strained paracyclophane moiety contains a bent aromatic ring.