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Synfacts 2006(10): 1046-1046
DOI: 10.1055/s-2006-949312
DOI: 10.1055/s-2006-949312
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Functionalization of Unactivated Positions in α-Amino Acid Derivatives
B. V. S. Reddy, L. R. Reddy, E. J. Corey*
Harvard University, Cambridge, USA
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. September 2006 (online)
Significance
The modification of natural amino acids is a straightforward route to useful unnatural or rare amino acids, which are constituents of important biologically active compounds. Herein, an elegant route for the functionalization of β- andγ-positions of natural leucine and isoleucine, based on an interesting Pd-mediated C-H activation, is described. It allows obtaining acetoxylated or arylated amino derivatives in very good yields and excellent diastereoselectivities in a single synthetic step.