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Synfacts 2006(10): 1048-1048
DOI: 10.1055/s-2006-949311
DOI: 10.1055/s-2006-949311
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York
Co-Catalyzed Conjugate Addition of Aryl Halides to Activated Olefins
M. Amatore, C. Gosmini*, J. Périchon
Université Paris 12, Thiais, France
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. September 2006 (online)
![](https://www.thieme-connect.de/media/synfacts/200610/lookinside/thumbnails/10.1055-s-2006-949311-1.jpg)
Significance
The conjugate addition of organometallic reagents to the double bond of electron-deficient olefins is a very powerful method of the formation of new C-C bonds. The authors developed a novel, very simple and convenient method of direct addition of aryl halides, including chlorides, and triflates to Michael acceptors like acrylonitrile and acrylate esters. Inexpensive cobalt bromide and 2,2′-bipyridine are used as catalysts. The reaction gives good yields both for electron-rich and electron-poor arenes and tolerates a number of functional groups.