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Synfacts 2006(10): 1081-1081
DOI: 10.1055/s-2006-949295
DOI: 10.1055/s-2006-949295
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York
Silica-Supported Phosphomolybdic Acid Catalyst for the Ferrier Reaction
J. S. Yadav*, M. Satyanarayana, E. Balanarsaiah, S. Raghavendra
Indian Institute of Chemical Technology, Hyderabad, India
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
21. September 2006 (online)
![](https://www.thieme-connect.de/media/synfacts/200610/lookinside/thumbnails/10.1055-s-2006-949295-1.jpg)
Significance
A recyclable silica-supported phosphomolybdic acid catalyst (PMA-SiO2) promoting the Ferrier reaction was developed. PMA-SiO2 was prepared from H3PMo12O40 and silica gel in MeOH at room temperature. The Ferrier reaction of triacetyl glucal with allyltrimethylsilane by using the catalyst was performed at room temperature to give α-4,6-di-O-acetyl-2,3-unsaturated C-allyl glycoside in 89% yield. The catalyst was reused five times without loss of catalytic activity. Eighteen examples of the Ferrier reaction with various nucleophiles such as alcohols and thiols were demonstrated (84-94% yield).