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Horm Metab Res 2006; 38(8): 497-500
DOI: 10.1055/s-2006-948770
Original Basic

© Georg Thieme Verlag KG Stuttgart · New York

Weight Loss with Long-term Intermittent Treatment with Oral Oleoyl-estrone in Lean Zucker Male Rats

B. García-Peláez 1 , S. Gómez-Ollés 1 , A. Salas 1 , X. Remesar 1
  • 1Department de Nutrició i Bromatologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
Further Information

Publication History

Received 16 November 2005

Accepted after revision 6 February 2006

Publication Date:
29 August 2006 (online)

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Abstract

To determine whether or not the long-term intermittent treatment with oleoyl-estrone (OE) in rats induces a cumulative weight loss, adult male rats were treated with OE over three alternating 10-day periods, with a 30-day “recovery” period occurring between each period. At the end of the third treatment period, the rats were allowed to recover and were then mated with females. Each treatment period produced a decrease of ca. 7% in body weight with no rebound during the recovery periods, whereas weight changed at the same pace in controls. The greatest difference in body weight was observed during the last days of treatment. OE-treated rats retained their initial protein pools throughout the treatment. Furthermore, treated and control males remained fertile and were able to procreate. Thus, we can conclude that intermittent OE treatment induces a cumulative weight loss in adult male rats.

Key words

Oleoyl-estrone - intermittent treatment - fertility - weight loss - body protein

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Correspondence

Prof. Dr. Xavier Remesar

Departament de Nutrició i Bromatologia·Facultat de Biologia·Universitat de Barcelona

Av. Diagonal 645·08028 Barcelona·Spain

Phone: +34/93/402 15 18

Fax: +34/93/403 70 64

Email: xremesar@ub.edu

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