Synlett 2006(12): 1965-1967  
DOI: 10.1055/s-2006-948162
LETTER
© Georg Thieme Verlag Stuttgart · New York

Efficient Synthesis of 2-Substituted Imidazoles by Palladium-Catalyzed Cross-Coupling with Benzylzinc Reagents

Josefin E. Utas, Berit Olofsson, Björn Åkermark*
Stockholm University, Department of Organic Chemistry, Arrhenius Laboratory, 106 91 Stockholm, Sweden
Fax: +46(8)154908; e-Mail: Bjorn.Akermark@organ.su.se;
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Received 28 March 2006
Publikationsdatum:
24. Juli 2006 (online)

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Abstract

Substituted benzylzinc reagents have been used in novel cross-coupling reactions with 2-iodo imidazoles to form compounds containing both a phenol and an imidazole moiety. The ­intramolecular hydrogen-bonding properties of these compounds were subsequently studied.

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