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DOI: 10.1055/s-2006-947336
Sodium Hydrogen Sulfate: Safe and Efficient
Publication History
Publication Date:
24 July 2006 (online)
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Introduction
Although NaHSO4 has been known for a long time, only in recent years it emerged as an efficient catalyst in organic chemistry. The new interest in this salt is due to environmental and economical considerations that prompt urgent need to redesign important chemical processes using suitable catalysts. NaHSO4 can be used alone or supported on alumina [1] or silica gel, in solvent or under solvent-free conditions. The most often used form of it is the silica gel supported form. This catalyst promotes various transformations like selective and regioselective protection and deprotection, [2-9] nitration, [10] nitrosation, [11] oxidation, [12] Beckman rearrangement, [1] synthesis of halide derivatives, [13] [14] coupling of indoles, [15] and synthesis of quinazolinones.16
The advantages of using NaHSO4 include operational simplicity, selectivity, and availability, and it is inexpensive and ecologically friendly.
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