Cytotoxic Compounds of Schizolaena hystrix from the Madagascar Rainforest

Abstract

Bioassay-guided fractionation of a crude ethanol extract from a Madagascar collection of Schizolaena hystrix afforded the two new long-chain compounds, 3S-acetoxyeicosanoic acid ethyl ester (1) and 3S-acetoxydoeicosanoic acid (2), and the known long-chain compound 3S-acetoxyeicosanoic acid (3). In addition, the long-chain alcohol 1-hydroxydodecan-2-one (7), as well as the new flavonoid schizolaenone C (4) and the two known flavonoids diplacol (5) and 3′-prenylnaringenin (6) were isolated from a methanol extract of the same plant. Isolation and structure elucidation of the novel compounds and the cytotoxicities of all the isolates are reported.

References

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