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Planta Med 2006; 72(9): 771-785
DOI: 10.1055/s-2006-946682
Review
© Georg Thieme Verlag KG Stuttgart · New York

The Assessment of Plant Metabolite Profiles by NMR-Based Methodologies

Elaine Holmes1 , Huiru Tang2 , Yulan Wang1 , Christoph Seger3
  • 1Biological Chemistry, Biomedical Sciences Division, Faculty of Natural Science, Imperial College, London, U.K.
  • 2State Key Laboratory of Magnetic Resonance and Molecular and Atomic Physics, Wuhan Magnetic Resonance Centre, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan, P.R. China
  • 3Institute of Pharmacy/Pharmacognosy, Centre of Molecular Biosciences, University of Innsbruck, Innsbruck, Austria
Weitere Informationen

Publikationsverlauf

Received: April 13, 2006

Accepted: May 16, 2006

Publikationsdatum:
17. Juli 2006 (online)

Auch verfügbar auf
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Abstract

NMR-based metabolic profiling techniques can simultaneously track changes in many plant metabolites and have found a number of applications in both systems biology and biosafety. Together with multivariate statistical analyses, NMR spectroscopy has been successfully applied to the characterisation of various herbs and plant products for quality control, authentication, determining geographical origin and for detecting adulteration of products. Additionally, the metabolic consequences of plant extracts have been demonstrated in experimental animals and in man using NMR-based metabonomics approaches to characterise the response. Here the application of NMR spectroscopy and chemometric tools for analysing plant-based products and their metabolic consequences are considered with particular emphasis on deconvolving biological complexity and minimising confounding biological variability with analytical ‘noise’.

Key words

NMR - metabolic profiling - metabolic fingerprinting - metabolomics - metabonomics - phytomedicines - traditional Chinese medicine - genetically modified plants - toxicology - xenobiotics

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Dr. Christoph Seger

Institute of Pharmacy/Pharmacognosy

Centre of Molecular Biosciences

University of Innsbruck

Innrain 52

6020 Innsbruck

Austria

Telefon: +43-512-507-5344

Fax: +43-512-507-2939

eMail: christoph.seger@uibk.ac.at