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DOI: 10.1055/s-2006-945114
© Georg Thieme Verlag KG Stuttgart · New York
Primary NK-/T-cell lymphoma of the gastrointestinal tract: clinical characteristics and endoscopic findings
Publikationsverlauf
eingereicht 20 February 2006
akzeptiert 4 August 2006
Publikationsdatum:
11. Januar 2007 (online)
![](https://www.thieme-connect.de/media/endoscopy/200702/lookinside/thumbnails/10.1055-s-2006-945114-1.jpg)
Background and study aims: Primary NK-/T-cell lymphoma of the gastrointestinal tract is a very rare disease with a poor prognosis. The aim of this study was to determine the clinical and endoscopic characteristics of patients with primary gastrointestinal NK-/T-cell lymphoma.
Patients and methods: The clinical features of 14 patients with primary gastrointestinal NK-/T-cell lymphoma and the endoscopic findings in 11 of these patients were reviewed. Their median age was 42 years (range 23 - 78) at the time of diagnosis.
Results: The initial presenting symptoms of primary gastrointestinal NK-/T-cell lymphoma were gastrointestinal bleeding (n = 6, 42 %), abdominal pain (n = 4, 29 %), and epigastric soreness (n = 4, 29 %). The disease was at an advanced stage at the time of diagnosis: stage II in 5 patients (36 %); stage III in 4 (28 %); and stage IV in 5 (36 %). Initial treatment was with chemotherapy (n = 8, 57 %) or surgical resection (n =5, 36 %). The median survival for all patients was 9 months. On endoscopy in 11 patients, the anatomic location of the primary lesion was found to be: stomach, n = 3 (27 %); esophagus, n =2 (18 %); duodenum, n = 1 (9 %); and the ileocolonic area, n = 5 (46 %). These lesions were ulceroinfiltrative in 4 cases (36 %), ulcerative in 3 cases (27 %), superficial/erosive in 3 cases (27 %), and infiltrative in 1 case (9 %). No prominent fungating mass was seen in any patient.
Conclusions: Primary gastrointestinal NK-/T-cell lymphoma was endoscopically characterized by superficial/erosive, ulcerative, or ulceroinfiltrative lesions without fungating mass. The most common presenting symptom was gastrointestinal bleeding. Despite aggressive treatments, the prognosis was very poor.
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J. H. Lee, MD
Division of Gastroenterology, Samsung Medical Center, Sungkyunkwan University School of Medicine
Irwon-Dong 50, Gangnam-gu
Seoul, Korea 135-710
Fax: +82-2-34103849
eMail: leejh@smc.samsung.co.kr