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Synthesis 2006(18): 3134-3140
DOI: 10.1055/s-2006-942502
DOI: 10.1055/s-2006-942502
SPECIALTOPIC
© Georg Thieme Verlag Stuttgart · New York
Efficient Syntheses of Polyamines Bearing 1H-Tetrazol-5-yl Units on Their Amino Functions
Further Information
Received
31 March 2006
Publication Date:
19 July 2006 (online)
Publication History
Publication Date:
19 July 2006 (online)
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Abstract
Linear N-benzyl-N′-trityl-α,ω-diamines and N α, N ω-ditritylpolyamines were efficiently converted into the corresponding N-(1-benzyltetrazol-5-yl)-substituted derivatives upon treatment with benzyl isothiocyanate followed by reaction of the thus-obtained thioureas with azidotrimethylsilane under Mitsunobu reaction conditions.
Key words
polyamines - tetrazoles - Mitsunobu reaction - thiourea derivatives - azidotrimethylsilane
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