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DOI: 10.1055/s-2006-942440
Recent Progress in Diaryl Ether Synthesis
Publication History
Publication Date:
29 June 2006 (online)
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Abstract
Diaryl ethers form an important class of organic compounds, both in life sciences and in the polymer industry. In general, diaryl ethers can be synthesized by means of copper-catalyzed Ullmann diaryl ether coupling, palladium-catalysed Buchwald-Hartwig reaction, nucleophilic aromatic substitution, arylboronic acid diaryl ether coupling, oxidative coupling, and nucleophilic aromatic addition to metal-arene complexes. This review covers the progress in diaryl ether synthesis since 1999, with literature coverage through September 2005.
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1 Introduction
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2 Ullmann and Buchwald-Hartwig Diaryl Ether Coupling Reactions
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2.1 Intermolecular Ullmann Diaryl Ether Coupling Reactions
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2.2 Intermolecular Palladium-Catalyzed Diaryl Ether Coupling Reactions
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2.3 Intramolecular Palladium- and Copper-Mediated Diaryl Ether Coupling Reactions
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3 Synthesis of Diaryl Ethers via Nucleophilic Aromatic Substitution
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3.1 Intermolecular Nucleophilic Aromatic Substitution
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3.2 Intramolecular Nucleophilic Aromatic Substitution
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4 Coupling of Phenols with Arylboronic Acids
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4.1 Intermolecular Coupling of Phenols with Arylboronic Acids
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4.2 Intramolecular Coupling of Phenols with Arylboronic Acids
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5 Diaryl Ether Synthesis via Benzyne Mechanism
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6 SnAr Additions to Metal-Arene Complexes
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6.1 Intermolecular SnAr Additions to Metal-Arene Complexes
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6.2 Intramolecular SnAr Additions to Metal-Arene Complexes
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7 Diaryl Ether Synthesis via Oxidative Coupling
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8 Diaryl Ether Synthesis by Fischer Chromium Carbene Mediated Benzannulation
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9 Summary
Key words
diaryl ether - Ullmann reaction - coupling reactions - Buchwald-Hartwig reaction - arylboronic acids
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