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Synfacts 2006(8): 0769-0769
DOI: 10.1055/s-2006-941971
DOI: 10.1055/s-2006-941971
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York
Asymmetric Synthesis of N- and O-Heterocycles Using Sequential Ru-Pd Catalysis
B. M. Trost*, M. R. Machacek, B. D. Faulk
Stanford University, USA
Further Information
Publication History
Publication Date:
21 July 2006 (online)
![](https://www.thieme-connect.de/media/synfacts/200608/lookinside/thumbnails/10.1055-s-2006-941971-1.jpg)
Significance
A sequential, two-catalyst process for the asymmetric synthesis of 5-, 6-, and 7-membered N- or O-heterocycles with high regio- and stereoselectivity is reported. The thermodynamically disfavored trans diastereomers may be obtained using both R,R and S,S ligands. The practical utility of this methodology was demonstrated by the highly efficient synthesis of the ring B fragment previously used for the construction of the potent anticancer bryostatin natural products.