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Synfacts 2006(8): 0758-0758
DOI: 10.1055/s-2006-941938
DOI: 10.1055/s-2006-941938
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (±)-Aspidospermidine
L. A. Sharp, S. Z. Zard*
École Polytechnique, Palaiseau, France
Further Information
Publication History
Publication Date:
21 July 2006 (online)
![](https://www.thieme-connect.de/media/synfacts/200608/lookinside/thumbnails/10.1055-s-2006-941938-1.jpg)
Significance
Interest in the synthesis of aspidospermidine stems from its structural relationship to other important biologically active alkaloids such as vindoline, the lower half of the antitumoral bis-indole alkaloid vinblastine. Sharp and Zard exploited a radical cyclization cascade to efficiently access the core of aspidospermidine in diastereoselective fashion (F → I).