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Synfacts 2006(8): 0756-0756  
DOI: 10.1055/s-2006-941936
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (S)-Camptothecin

Contributor(s): Philip Kocienski
R. Peters*, M. Althaus, A.-L. Nagy
Hoffmann-La Roche Synthesis and Process Research, Basel, Switzerland
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Publikationsdatum:
21. Juli 2006 (online)

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Significance

The quest for a practical and scalable synthesis of the promising anti-cancer drug (S)-camptothecin continues. This synthesis uses (-)-8-phenylmenthol as a chiral auxiliary in order to establish the single stereogenic center in intermediate B.