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Synfacts 2006(8): 0761-0761  
DOI: 10.1055/s-2006-941925
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of (±)-UCS1025A

Contributor(s): Philip Kocienski, Thomas Snaddon
T. R. Hoye*, V. Dvornikovs
University of Minnesota, Minneapolis, USA
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Publikationsverlauf

Publikationsdatum:
21. Juli 2006 (online)

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Significance

Isolated from the fermentation broth of Acremonium sp., UCS1025A exhibits antimicrobial and cytotoxic activity as well as the ability to inhibit telomerase. This synthesis by Hoye and Dvornikovs explores the biomimetic formation of the octalin portion by an intramolecular Diels-Alder reaction.