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Synfacts 2006(7): 0680-0680  
DOI: 10.1055/s-2006-941858
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Pd-Catalyzed Asymmetric Synthesis ofα-Alkylidene-γ-butyrolactams

Contributor(s): Mark Lautens, Yann Béthuel
W. Xu, A. Kong, X. Lu*
Shanghai Institute of Organic chemistry, P. R. of China
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Publication History

Publication Date:
22 June 2006 (online)

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Significance

γ-Butyrolactams possess a wide range of biological activity, which make them valuable scaffolds in medicinal chemistry. They have been synthesized in good yield and enantioselectivity by a Pd(II)-catalyzed cyclization of 4′-X-2′-butenyl 2-alkynoates (X = leaving group) in the presence of a chiral nitrogen-containing ligand.