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Synfacts 2006(7): 0637-0637
DOI: 10.1055/s-2006-941826
DOI: 10.1055/s-2006-941826
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York
Synthesis of (±)-Rolipram
K. Tonogaki, K. Itami*, J.-I. Yoshida*
Kyoto University and Nagoya University, Japan
Further Information
Publication History
Publication Date:
22 June 2006 (online)
Significance
Rolipram is a selective inhibitor of phosphodiesterase-4. It is an antiinflammatory agent and an antidepressant. This latest in a long list of syntheses boasts a Pd-catalyzed three-component coupling to generate a vinylboronate intermediate which then undergoes a subsequent Pd-catalyzed carbonylation.