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Synfacts 2006(7): 0692-0692
DOI: 10.1055/s-2006-941816
DOI: 10.1055/s-2006-941816
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York
Direct Catalytic Asymmetric Mannich Reaction via a Dinuclear Zinc Catalyst
B. M. Trost*, J. Jaratjaroonphong, V. Reutrakul*
Stanford University, USA and Mahidol University Bankok, Thailand
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. Juni 2006 (online)
![](https://www.thieme-connect.de/media/synfacts/200607/lookinside/thumbnails/10.1055-s-2006-941816-1.jpg)
Significance
The authors have found that different imine protecting groups provide different diastereoselectivity in the direct Mannich reaction. The use of their dinuclear zinc catalyst results in good yields and high selectivities for the condensation of α-hydroxy ketones and imines. The use of enolizable imines was tolerated with various alkyl-substituted imine substrates giving good results.