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Diabetologie und Stoffwechsel 2006; 1(3): 181-186
DOI: 10.1055/s-2006-941556
Übersicht
© Georg Thieme Verlag KG Stuttgart · New York

Lipoproteine und Zielwerte bei Diabetes mellitus

Lipoproteins and Target Values in Diabetes MellitusD. Müller-Wieland1 , J. Kotzka1
  • 1Institut für Klinische Biochemie und Pathobiochemie
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Publikationsverlauf

Manuskript eingegangen am 18.3.2006

revidiertes Manuskript angenommen am 24.3.2006

Publikationsdatum:
19. Mai 2006 (online)

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Zusammenfassung

Patienten mit Diabetes mellitus sind in den allermeisten Fällen kardiovaskuläre Hochrisikopatienten. Deswegen sollte ein Zielwert für LDL-Cholesterin im Plasma < 100 mg/dl (2,6 mmol/l) angestrebt bzw. eine mindestens 30 - 40 %-ige Reduktion bei bereits niedrigen Ausgangswerten erreicht werden. Bei Patienten mit Diabetes und kardiovaskulären Komplikationen ist aufgrund der neuen Studienlage die Absenkung des LDL-Cholesterin < 70 mg/dl (1,8 mmol/l) eine gerechtfertigte therapeutische Option. In dieser Übersicht werden zudem Prinzipien der Pathogenese einer diabetischen Dyslipidämie skizziert und das grundsätzliche Vorgehen bei zusätzlich erhöhten Triglyzeriden und niedrigem HDL-Cholesterin vor dem Hintergrund klinischer Endpunktstudien dargestellt.

Abstract

Patients with diabetes mellitus have in most cases a high cardiovascular risk. Therefore a target value for LDL-Cholesterol < 100 mg/dl (2,6 mmol/l) or at least a reduction by 30 - 40 % in case of low basal levels is recommended. In patients with diabetes and cardiovaskular complications recents studies have provided evidence that lowering of LDL-Cholesterol below 70 mg/dl (1,8 mmol/l) is considered as a justified therapeutic option. In addition, this review will outline some principal mechanisms of the pathogenesis of diabetic dyslipidemia and basic aspects how to procede in case triglyceride levels are elevated and HDL-Cholesterol is low.

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D. Müller-Wieland

Institut für Klinische Biochemie und Pathobiochemie

Deutsches Diabetes-Zentrum an der Heinrich-Heine-Universität Düsseldorf

Leibniz-Zentrum für Diabetes-Forschung

Auf’m Hennekamp 65

40225 Düsseldorf

Telefon: 0211/3382-240

Fax: 0211/3382-430

eMail: mueller-wieland@ddz.uni-duesseldorf.de