Synlett 2006(6): 841-844  
DOI: 10.1055/s-2006-939052
LETTER
© Georg Thieme Verlag Stuttgart · New York

Thiourea-Catalyzed Direct Reductive Amination of Aldehydes

Dirk Menche*, Fatih Arikan
Gesellschaft für Biotechnologische Forschung mbH, Medizinische Chemie, Mascheroder Weg 1, 38124 Braunschweig, Germany
Fax: +49(531)6181461; e-Mail: dme05@gbf.de;
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Publikationsverlauf

Received 20 January 2006
Publikationsdatum:
14. März 2006 (online)

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Abstract

A hydrogen-bond-catalyzed direct reductive amination of aldehydes is reported. The acid- and metal-free process uses thiourea as organocatalyst and the Hantzsch ester for transfer-hydrogenation and allows for the high-yielding synthesis of diverse amines.