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Synfacts 2006(5): 0477-0477  
DOI: 10.1055/s-2006-934358
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Chiral Functionalized Diarylmethanols Catalyzed by a New γ-Amino Thiol

Contributor(s): Mark Lautens, Yann Béthuel
P-Y. Wu, H-L. Wu, B-J. Uang*
National Tsing Hua University, Hsinchu, Taiwan
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Publication History

Publication Date:
21 April 2006 (online)

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Significance

Chiral diaryl methanols are important scaffolds in medicinal chemistry. This paper describes the enantioselective aryl transfer reaction to aldehydes using a γ-amino thiol ligand and aryl boronic acids as the aryl source without any need of a polyether additive.