A Versatile Method for Suzuki Cross-Coupling of Nitrogen Heterocycles

Significance

Despite the tremendous number of recently developed highly active catalysts for Suzuki cross-coupling reactions, a coupling reaction of nitrogen-containing heterocycles may sometimes be a significant challenge. In this publication, a general and robust protocol for the Suzuki cross-coupling of various types of aza-heterocycles is presented. The method uses inexpensive tricyclohexylphosphine as a ligand and a relatively low amount (1 mol%) of palladium catalyst. Even the often unreactive electron-rich aryl chlorides can be successfully involved in the cross-coupling reaction under these conditions.