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Synlett 2006(4): 0605-0609
DOI: 10.1055/s-2006-932479
DOI: 10.1055/s-2006-932479
LETTER
© Georg Thieme Verlag Stuttgart · New York
Indium(I) Bromide Mediated Coupling of α,α-Dichloroketones with Carbonyl Compounds in Aqueous Media: The Preparation of 2-Chloro-3-hydroxypropan-1-one Derivatives
Further Information
Publication History
Received
7 November 2005
Publication Date:
20 February 2006 (online)


Abstract
Indium(I) bromide promotes the reductive coupling of α,α-dichloroketones with carbonyl compounds to the corresponding 2-chloro-3-hydroxypropan-1-one derivatives in moderate to good yields.
Key words
indium(I) bromide - dichloroketones - halogenomethyl indium(III) - 2-chloro-3-hydroxypropan-1-one - Darzens condensation