Synlett 2006(4): 0605-0609  
DOI: 10.1055/s-2006-932479
LETTER
© Georg Thieme Verlag Stuttgart · New York

Indium(I) Bromide Mediated Coupling of α,α-Dichloroketones with Carbonyl Compounds in Aqueous Media: The Preparation of 2-Chloro-3-hydroxy­propan-1-one Derivatives

Clovis Peppe*, Rafael Pavão das Chagas
Departamento de Química, Universidade Federal de Santa Maria-UFSM, Campus UFSM, Santa Maria, RS, 97105-900, Brazil
Fax: +55(55)32208031; e-Mail: peppe@quimica.ufsm.br;
Further Information

Publication History

Received 7 November 2005
Publication Date:
20 February 2006 (online)

Zoom Image

Abstract

Indium(I) bromide promotes the reductive coupling of α,α-dichloroketones with carbonyl compounds to the corresponding 2-chloro-3-hydroxypropan-1-one derivatives in moderate to good yields.