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Synfacts 2006(4): 0404-0404
DOI: 10.1055/s-2006-932089
DOI: 10.1055/s-2006-932089
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart · New York
The Synthesis of 1,3,4-Oxadiazoles by Using PS-PPh3
Y. Wang*, D. R. Sauer, S. W. Djuric
Abbott Laboratories, Abbott Park, USA
Further Information
Publication History
Publication Date:
24 March 2006 (online)
Significance
The one-step synthesis of 1,3,4-oxadiazoles by using commercially available PS-PPh3 resin was demonstrated. 1,3,4-Oxadiazoles were prepared from a variety of carboxylic acids and acid hydrazides by using PS-PPh3 resin and trichloroacetonitrile at 150 °C in acetonitrile with microwave heating (11 examples).