Synthesis of (-)-Norsecurinine

R. Alibés; P. Bayón; P. de March; M. Figueredo; J. Font; E. García-García; D. González-Gálvez

doi:10.1055/s-2006-932030

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Synfacts 2006(4): 0305-0305
DOI: 10.1055/s-2006-932030

Synthesis of Natural Products and Potential Drugs

Synthesis of (-)-Norsecurinine

Contributor(s): Philip Kocienski, John Cooksey
R. Alibés, P. Bayón, P. de March, M. Figueredo*, J. Font, E. García-García, D. González-Gálvez
Universitat Autònoma de Barcelona, Spain

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Publication History

Publication Date:
24 March 2006 (online)

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Significance

A single stereogenic center established at the very outset of the synthesis, using a Pd-catalyzed asymmetric imide alkylation of epoxide B, directs the construction of the remaining three stereogenic centers by substrate-controlled processes.