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Synfacts 2006(3): 0191-0191  
DOI: 10.1055/s-2006-931919
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Clavolonine

Contributor(s): Philip Kocienski, John Cooksey
D. A. Evans*, J. R. Scheerer
Harvard University, Cambridge, USA
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Publication History

Publication Date:
21 February 2006 (online)

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Significance

Clavolonine is a lycopodium alkaloid isolated from Lycopodium clavatum. The Evans group applies a feast of intramolecular cascade cyclization reactions in their synthesis of Clavolonine and several related compounds starting from a readily accessible precursor. This synthetic strategy offers an alternative to those previously reported which make use of a linear approach using cyclic starting materials.