Abstract
Nine new 7α,20-epoxy-ent -kaurane diterpenoids, parvifolines O - W (1 - 9 ), together with five known analogues, lasiocarpanin (10 ), rosthorin A (11 ), longikaurin E (12 ), adenolin D (13 ) and longikaurin B (14 ), were isolated from the leaves of Isodon parvifolius . Their structures were determined by means of spectroscopic analysis. Selected diterpenoids (1 - 10 ) were tested for their antiproliferative activity against A549, HT-29 and K562 cells. Compounds 3 , 7 , 8 and 10 showed moderate inhibitory activity against all three cell lines.
Key words
Isodon parvifolius
- Labiatae - diterpenoids -
ent -kauranes - parvifolines O - W - antiproliferative activity
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Prof. Dr. Han-Dong Sun
State Key Laboratory of Phytochemistry and Plant Resources in West China
Kumming Institute of Botany
Chinese Academy of Sciences
Heilongtan
Kunming 650204
People’s Republic of China
Fax: +86-871-521-6343
eMail: hdsun@mail.kib.ac.cn