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DOI: 10.1055/s-2006-931557
Phytochemical and Pharmacological Studies on the Acetonic Extract of Marrubium globosum ssp. libanoticum
Publikationsverlauf
Received: June 7, 2005
Accepted: December 2, 2005
Publikationsdatum:
24. April 2006 (online)
![](https://www.thieme-connect.de/media/plantamedica/200606/lookinside/thumbnails/10.1055-s-2006-931557-1.jpg)
Abstract
A new natural labdane diterpene, marrulibanoside, was isolated from the acetonic extract of aerial parts of M. globosum Montbr. et Auch. ex Benth. ssp. libanoticum Boiss. (Lamiaceae). Its structure was determined by spectroscopic methods such as 1D and 2D NMR and mass spectrometry. Pharmacological studies have shown that the extract of M. globosum exerts anti-inflammatory effects in the rat paw oedema induced by carrageenin resulting in reduced paw swelling. This activity, which seems due to marrulibanoside, is a consequence of iNOS and COX-2 activities inhibition.
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Prof. Maurizio Bruno
Dipartimento di Chimica Organica ”E. Paternò”
Università di Palermo
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