Z Gastroenterol 2006; 44(10): 1065-1072
DOI: 10.1055/s-2006-927142
Übersicht

© Karl Demeter Verlag im Georg Thieme Verlag KG Stuttgart · New York

ASCO-Update 2006 - Neuigkeiten vom 42. Meeting der American Society of Clinical Oncology/ASCO 2006

ASCO Update 2006 - Highlights of the 42. Meeting of the American Society of Clinical Oncology/ASCO 2006A. Reinacher-Schick1 , D. Arnold2 , F. Lordick3 , M. Möhler4 , M. P. Lutz5 , T. Seufferlein6 [*] 1
  • 1Medizinische Universitätsklinik, Knappschaftskrankenhaus, Ruhr-Universität Bochum
  • 2Klinik für Innere Medizin IV, Universität Halle
  • 3III. Medizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München
  • 4I. Medizinische Klinik und Poliklinik, Universität Mainz
  • 5Medizinische Klinik, Caritasklinik St. Theresia, Saarbrücken
  • 6Klinik für Innere Medizin I, Universitätsklinikum Ulm
Further Information

Publication History

Publication Date:
25 October 2006 (online)

Zusammenfassung

Kaum ein Gebiet der Gastroenterologie hat sich in den letzten Jahren so schnell entwickelt wie die Therapie gastrointestinaler Tumoren, nicht zuletzt durch den Einsatz von Targeted Therapies. Wir möchten Ihnen in der folgenden Übersicht wie bereits im vergangenen Jahr [22] die wichtigsten neuen klinischen Studien zu Ösophagus-, Magen-, kolorektalen, Pankreas-, Leber- und Gallenwegskarzinomen vorstellen und bewerten, die auf dem diesjährigen Meeting der American Society of Clinical Oncology präsentiert wurden.

Abstract

Currently, the treatment of gastrointestinal cancers is rapidly changing due to the implementation of novel chemotherapeutic agents as well as the introduction of targeted therapies into treatment protocols. The following review will give an overview on the most important clinical trials in esophageal, gastric, colorectal, pancreatic and hepatobiliary cancer that were presented at the annual meeting of the American Society of Clinical Oncology.

Literatur
(Angegeben sind jeweils die Nummern der Abstracts, die unter www.asco.org eingesehen werden können)

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  • 2 Arnold D. et al . , Phase I/II study of cetuximab, capecitabine and oxaliplatin (CAPOX) combined with standard radiotherapy (RTX) as neoadjuvant treatment of advanced rectal cancer (RC).  JCO. 2006;  24 (18S) A3574
  • 3 Bosset J F. et al . Preoperative radiation (Preop RT) in rectal cancer: effect and timing of additional chemotherapy (CT) 5-year results of the EORTC 22 921 trial.  JCO. 2005;  23 A3505
  • 4 Carr B I. et al . Gemcitabine hepatic arterial chemoembolization (TACE) in the treatment of unresectable HCC.  JCO. 2006;  24 (18S) A4141
  • 5 Cassidy J. et al . Randomized double blind (DB) placebo (Plcb) controlled phase III study assessing the efficacy of xaliproden (X) in reducing the cumulative peripheral sensory neuropathy (PSN) induced by the oxaliplatin (Ox) and 5-FU/LV combination (FOLFOX4) in first-line treatment of patients (pts) with metastatic colorectal cancer (MCRC).  JCO. 2006;  24 (18S) A3507
  • 6 Chauffert C. et al . Phase III trial comparing initial chemoradiotherapy (intermittent cisplatin and infusional 5-FU) followed by gemcitabine vs. gemcitabine alone in patients with locally advanced non metastatic pancreatic cancer: A FFCD-SFRO study.  JCO. 2006;  24 (18S) A4008
  • 7 Chung K Y. et al . Phase I trial of preoperative cetuximab with concurrent continuous infusion 5-fluorouracil and pelvic radiation in patients with local-regionally advanced rectal cancer.  JCO. 2006;  24 (18S) A3560
  • 8 Cohn A. et al . Single-agent pemetrexed in patients with advanced and metastatic hepatoma.  JCO. 2006;  24 (18S) A14064
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  • 10 Cunningham D. et al . Randomised multicentre phase III study comparing capecitabine with fluorouracil and oxaliplatin with cisplatin in patients with advanced oesophagogastric (OG) cancer: The REAL 2 trial.  JCO. 2006;  24 (18S) LBA4017
  • 11 Czito B G. et al . Preliminary results of a phase I study of external beam radiation therapy (EBRT), oxaliplatin (OX), bevacizumab (BV), and capecitabine (CAP) for locally advanced or metastatic adenocarcinoma of the rectum.  JCO. 2006;  24 (18S) A3543
  • 12 Di Fabio F. et al . 18FDG-PET in targeted therapy with cetuximab in gastric or gastroesophageal junction (GEJ) adenocarcinoma: First results of the Italian FOLCETUX Study.  JCO. 2006;  24 (18S) A4061
  • 13 Eckel F. et al . Chemotherapy in advanced biliary tract carcinoma (BTC): A comprehensive analysis.  JCO. 2006;  24 (18S) A14036
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  • 16 Fuchs C. et al . A randomized trial of first-line irinotecan/fluoropymidine combinations with or without celecoxib in metastatic colorectal cancer (BICC-C).  JCO. 2006;  24 (18S) A 3506
  • 17 Gerard J, Bonnetain F, Conroy T. et al . Preoperative (preop) radiotherapy (RT) + 5 FU/folinic acid (FA) in T3 - 4 rectal cancers: results of the FFCD 9203 randomized trial.  JCO. 2005;  23 A3504
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  • 19 Harder J. et al . Outpatient chemotherapy with gemcitabine and oxaliplatin in advanced biliary tract cancer; a phase II study.  JCO. 2006;  24 (18S) A14006
  • 20 Heinemann V. et al . Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer.  JCO. 2006;  24 3946-3952
  • 21 Hochster H S. et al . Safety and efficacy of oxaliplatin/fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer (mCRC): Final analysis of the TREE-Study.  JCO. 2006;  24 (18S) A3510
  • 22 Hohler T. et al . ASCO-Update 2005 - Highlights of the 41st Meeting of the American Society of Clinical Oncology/ASCO 2005.  Z Gastroenterol. 2005;  43 1253-1259
  • 23 Igbal S. et al . A phase II trial of gemcitabine and capecitabine in patients (pts) with unresectable or metastatic gallbladder cancer or cholangiocarcinoma.  JCO. 2006;  24 (18S) A4134
  • 24 Kang Y. et al . Randomized phase III trial of capecitabine/cisplatin (XP) vs. continuous infusion of 5FU/cisplatin (FP) as first-line therapy in patients (pts) with advanced gastric cancer (AGC): Efficacy and safety results.  JCO. 2006;  24 (18S) LBA4018
  • 25 Kawamoto T. et al . Amplification of HER-2/neu (erb2) gene expression in gallbladder (GBC) and in bile duct cancer (BDC) (biliary tract cancer, BTC).  JCO. 2006;  24 (18S) A4011
  • 26 Kindler H L. et al . A randomized phase II study of bevacizumab (B) and gemcitabine (G) plus cetuximab (C) or erlotinib (E) in patients (pts) with advanced pancreatic cancer (PC): A preliminary analysis.  JCO. 2006;  24 (18S) A4040
  • 27 Knox J J. et al . A phase II trial of oblimersen sodium (G3139) in combination with docorubicin (DOX) in advanced hepatocellular carcinoma (HCC). NCI protocol # 5789.  JCO. 2006;  24 (18S) A14072
  • 28 Ko A H. et al . A phase II study of gemcitabine (GEM) given at fixed-dose rate (FDR) infusion, low-dose cisplatin (CDDP), and bevacizumab in metastatic pancreatic cancer (PanCa).  JCO. 2006;  24 (18S) A4041
  • 29 Labianca R. et al . Alternating versus continuous „FOLFIRI” in advanced colorectal cancer (ACC): A randomized „GISCAD” trial.  JCO. 2006;  24 (18S) A3505
  • 30 Lin C. et al . Arsenic trioxide in patients with hepatocellular carcinoma: A phase II trial.  JCO. 2006;  24 (18S) A14129
  • 31 Machiels J P. et al . Phase I study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer.  JCO. 2006;  24 (18S) A3552
  • 32 Maindrault-Goebel F. et al . OPTIMOX2, a large randomized phase II study of maintenance therapy or chemotherapy-free intervals (CFI) after FOLFOX in patients with metastatic colorectal cancer (MRC). A GERCOR study.  JCO. 2006;  24 (18S) A3504
  • 33 Marijnen C. et al . Long term results, toxicity and quality of life in the TME trial.  ASCO Gastrointestinal Cancers Symposium. 2006;  A166
  • 34 Moehler M. et al . Irinotecan/capecitabine versus cisplatin/capecitabine in advanced adenocarcinoma of the stomach or gastroesophageal junction: Interim analysis of a randomized German AIO phase II study.  JCO. 2006;  24 (18S) A4032
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  • 36 Morinaga S. et al . Expression of Epidermal growth factor receptor (EGFR) associates with proliferation, apoptosis, and histologically aggressive features in hepatocellular carcinoma.  JCO. 2006;  24 (18S) A14039
  • 37 Nehls O. et al . A prospective multicenter phase II trial of capecitabine plus oxaliplatin (CapOx) in advanced biliary system adenocarcinomas: The final results.  JCO. 2006;  24 (18S) A4136
  • 38 Neuhaus P, Oettle H, Post S. et al . A randomised, prospective, multicenter, phase III trial of adjuvant chemotherapy with gemcitabine vs. observation in patients with resected pancreatic cancer.  JCO. 2005;  23 A4013
  • 39 Nordlinger P. et al . Complete radiological response of colorectal liver metastases (LM) chemotherapy: Does it mean cure?.  JCO. 2006;  24 (18S) A3501
  • 40 O’Dwyer P J. et al . Gefitinib in advanced unresectable hepatocellular carcinoma: Results from the Eastern Cooperative Oncology Group’s Study E1203.  JCO. 2006;  24 (18S) A4143
  • 41 Poplin E. et al . Phase III trial of gemcitabine (30-minute infusion) versus gemcitabine (fixed-dose-rate infusion[FDR]) versus gemcitabine + oxaliplatin(GEMOX) in patients with advanced pancreatic cancer (E6201).  JCO. 2006;  24 (18S) LBA4004
  • 42 Qin SK. et al . Preliminary results of a phase II trial of FOLFOX4 regimen in Chinese patients with unresectable primary liver cancer.  JCO. 2006;  24 (18S) A14065
  • 43 Quirke P. et al . Local recurrence after rectal cancer resection is strongly related to the plane of surgical dissection and is further reduced by pre-operative short course radiotherapy. Preliminary results of the Medical Research Council (MRC) CR07 trial.  JCO. 2006;  24 (18S) A3512
  • 44 Ramanathan R K. et al . Phase II study of lapatinib, a dual inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase 1 and 2 (Her2/Neu) in patients (pts) with advanced biliary tree cancer (BTC) or hepatocellular cancer (HCC). A California Consortium (CCC-P) Trial.  JCO. 2006;  24 (18S) A4010
  • 45 Regine W F. et al . RTOG 9704a phase III study of adjuvant pre and post chemoradiation (CRT) 5-FU vs. gemcitabine (G) for resected pancreatic adenocarcinoma.  JCO. 2006;  24 (18S) A4007
  • 46 Richards D A. et al . Phase II multicenter trial of docetaxel+oxaliplatin in stage IV gastroesophageal and/or stomach cancer.  JCO. 2006;  24 (18S) A4071
  • 47 Rizk N P. et al . Impact of pre-operative chemoradiotherapy on post-esophagectomy morbidity and mortality.  JCO. 2006;  24 (18S) A4025
  • 48 Roedel K. et al . Multicenter phase II trial of preoperative radiotherapy with concurrent and adjuvant capecitabine and oxaliplatin in locally advanced rectal cancer.  ASCO Gastrointestinal Cancer Symposium. 2006;  A349
  • 49 Sauer R. et al . Preoperative versus postoperative chemoradiotherapy for rectal cancer.  N Engl J Med. 2004;  351 1731-1740
  • 50 Schwartz J D. et al . Bevacizumab in unresectable hepatocellular carcinoma (HCC) for patients without metastasis and without invasion of the portal vein.  JCO. 2006;  24 (18S) A4144
  • 51 Sebag-Montefiore D. et al . Routine short course pre-op radiotherapy or selective post-op chemoradiotherapy for resectable rectal cancer? Preliminary results of the MRC CR07 randomised trial.  JCO. 2006;  24 (18S) A3511
  • 52 Shah M A. et al . Final results of a multicenter phase II study of irinotecan (CPT), cisplatin (CIS), and bevacizumab (BEV) in patients with metastatic gastric or gastroesophageal (GEJ) adenocarcinoma (NCI #6447).  JCO. 2006;  24 (18S) A4020
  • 53 Sharma A. et al . Gemcitabine and oxaliplatin (Gemox) in advanced/unresectable gall bladder cancer: A phase II study.  JCO. 2006;  24 (18S) A14027
  • 54 Siegel A B. et al . Current treatments, determinants of use, and survival for patients with hepatoma in the United States from 1998 - 2002.  JCO. 2006;  24 (18S) A4138
  • 55 Stahl M, Stuschke M, Lehmann N. et al . Chemoradiation with and without surgery in patients with locally advanced squamous cell carcinoma of the esophagus.  JCO. 2005;  23 2310-2317
  • 56 Tebbutt N. et al . Randomised phase II study evaluating weekly docetaxel in combination with cisplatin and 5FU or capecitabine in metastatic oesophago-gastric cancer.  JCO. 2006;  24 (18S) A4067
  • 57 Tepper J E. et al . Superiority of trimodality therapy to surgery alone in esophageal cancer: results of CALGB 9781.  JCO. 2006;  24 A 4012
  • 58 Urschel J D. et al . A meta-analysis of randomized controlled trials that compared neoadjuvant chemoradiation and surgery to surgery alone for resectable esophageal cancer.  Am J Surg. 2003;  185 538-543
  • 59 Venook A. et al . Phase III study of irinotecan/5FU/LV (FOLFIRI) or oxaliplatin/5FU/LV (FOLFOX) ± cetuximab for patients (pts) with untreated metastatic adenocarcinoma of the colon or rectum (MCRC): CALGB 80 203 preliminary results.  JCO. 2006;  24 (18S) A3509
  • 60 Willett C G. et al . Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer.  Nat Med. 2004;  10 145-147
  • 61 Yu S C. et al . Transarterial ethanol ablation of unresectable hepatocellular carcinoma with lipiodol-ethanol mixture (LEM): A phase II study.  JCO. 2006;  24 (18S) A14054
  • 62 Yu J. et al . A randomized clinical study of surgery versus radiotherapy in the treatment of resectable esophageal cancer.  JCO. 2006;  24 (18S) A4013
  • 63 Zhu A X. et al . Phase II study of cetuximab in patients with unresectable or metastatic hepatocellular carcinoma.  JCO. 2006;  24 (18S) A14096

1 für die Arbeitsgemeinschaft Gastroenterologische Onkologie der DGVS.

Thomas Seufferlein

Klinik für Innere Medizin I, Universitätsklinikum Ulm

Robert-Koch-Str. 8

89081 Ulm

Email: thomas.seufferlein@uniklinik-ulm.de